Abstract
The synthesis and development of a novel class of molecules that inhibit anthrax edema factor, an adenylyl cyclase, is reported. These molecules are derived from the initial discovery that histidine and imidazole adducts of the prostaglandin PGE(2) reduce the net secretory response of cholera toxin-challenged mice and act directly on the action of anthrax edema factor, a calmodulin-dependent adenylyl cyclase. The simple enones examined in this letter were prepared by palladium-catalyzed Suzuki reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenylyl Cyclases / chemistry*
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Adenylyl Cyclases / metabolism
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Animals
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Anthrax / metabolism*
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology*
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Antigens, Bacterial
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Bacillus anthracis / enzymology
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Bacterial Toxins
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Binding Sites
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Calmodulin / metabolism
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Catalysis
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Dinoprostone / metabolism
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Drug Design
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Ketones
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Mice
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Models, Chemical
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Palladium / chemistry
Substances
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Anti-Infective Agents
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Antigens, Bacterial
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Bacterial Toxins
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Calmodulin
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Ketones
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anthrax toxin
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Palladium
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Adenylyl Cyclases
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Dinoprostone